Non-Invasive Methods for Detecting Human Physiological and Psychological Conditions

We develop a machine learning model that uses video images of the human face to pick-up signals and analyze these signals to determine physiological conditions.  There are a multitude of applications for this research, from non-invasive measurement of clinical data (such temperature, blood pressure) to lie detection that could be used by law enforcement.

Reduced Order Modelling for Friction Stir Welding

Friction stir welding is a new method to fuse metals that are otherwise difficult to join.  This project explores reduced order modelling for friction stir welding.  The parameterization of the process requires complex computer simulations and human intuition.  We propose to simplify the process by developing a mathematical model to optimize the friction stir welding process.  Furthermore, we are interested in exploring how these methods may be applied to problems in other unrelated domains  such as health, energy materials, and/or nanophotonics.

Pulmonary Ventilator Perfusion Mismatch 

Develop a mathematical model and methodologies for evaluating pulmonary ventilation perfusion mismatch.  Ventilation/perfusion mismatch occurs in pulmonary diseases such as ARDS and COPD.  While low tidal volume ventilator strategy has shown a reduction in mortality rate of ARDS, there is no consensus among clinicians on other ventilator settings for ARDS patients.  Mathematical models or ARDS provide useful insights into the condition but they are not readily applicable to investigate ventilation/perfusion mismatch.  We are interested in deriving a measurement of the intrapulmonary shunt of a lung by using inhale and exhale gas fractions.  We would like to be able to identify differences in ventilation/perfusion mismatch induced by dead space and/or intrapulmonary shunt in the lung.


Habib, Faisal; Huang, Huaxiong; Gupta, Arvind; Wright, Tom

MERCI: A Machine Learning Approach to Identifying Hydroxychloroquine Retinopathy using mfERG Journal Article

In: Documenta Ophthalmologica, vol. 145, pp. 53-63, 2022, ISSN: 1573-2622.

Abstract | Links | BibTeX

Li, Shixuan; Pan, Ruiqi; Gupta, Arvind; Xu, Shixin; Fang, Yibin; Huang, Huaxiong

Predicting the risk of rupture for vertebral aneurysm based on geometric features of blood vessels Journal Article

In: Royal Society Open Science, vol. 8, no. 8, 2021, ISSN: 2054-5703.

Abstract | Links | BibTeX

Chen, Yu; Cheng, Jin; Gupta, Arvind; Huang, Huaxiong; Xu, Shixin

Numerical Method for Parameter Inference of Nonlinear ODEs with Partial Observations Journal Article

In: Royal Society Open Science, vol. 8, no. 7, 2021, ISSN: 2054-5703.

Abstract | Links | BibTeX

McCarthy, Zachary; Xu, Shixin; Rahman, Ashrafur; Bragazzi, Nicola Luigi; Corrales-Medina, Vicente F.; Lee, Jason; Seet, Bruce T.; Neame, Dion; Thommes, Edward; Heffernan, Jane; Chit, Ayman; Wu, Jianhong

Modelling the linkage between influenza infection and cardiovascular events via thrombosis Journal Article

In: Scientific Reports, vol. 10, 2020.

Abstract | Links | BibTeX

Xu, Shixin; Chang, Joshua C.; Chow, Carson C.; Brennan, KC; Huang, Huaxiong

A mathematical model for persistent post-CSD vasoconstriction Journal Article

In: PLOS Computational Biology , vol. 16, no. 7, 2020.

Abstract | Links | BibTeX

Shen, Lingyue; Huang, Huaxiong; Lin, Ping; Song, Zilong; Xu, Shixin

An energy stable C0 finite element scheme for a quasi-incompressible phase-field model of moving contact line with variable density Journal Article

In: Journal of Computational Physics, vol. 405, 2020, ISSN: 0021-9991.

Abstract | Links | BibTeX

Liao, Mai-Jia; Wei, Ming-Tzo; Xu, Shixin; Ou-Yang, H Daniel; Sheng, Ping

Non-Stokes drag coefficient in single-particle electrophoresis: New insights on a classical problem Journal Article

In: Chinese Physics B, vol. 28, no. 8, 2019.

Abstract | Links | BibTeX

Zhu, Yi; Xu, Shixin; Eisenberg, Robert S.; Huang, Huaxiong

A Bidomain Model for Lens Microcirculation Journal Article

In: Biophysical Journal, vol. 116, no. 6, pp. 1171-1184, 2019, ISSN: 0006-3495.

Abstract | Links | BibTeX

Zhao, Xiukun; Gold, Nathan; Fang, Yibin; Xu, Shixin; Zhang, Yongxin; Liu, Jianmin; Gupta, Arvind; Huang, Huaxiong

Vertebral artery fusiform aneurysm geometry in predicting rupture risk Journal Article

In: Royal Society Open Science, vol. 5, no. 10, 2018, ISSN: 2054-5703.

Abstract | Links | BibTeX

Aroda, Pavan; Guergachi, Aziz; Huang, Huaxiong

Application of the convolution operator for scenario integration with loss data in operational risk modeling Journal Article

In: Journal of Operational Risk, vol. 10, no. 4, pp. 23-44, 2015, ISSN: 17552710.

Abstract | Links | BibTeX